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In his column Sunday, Nicholas D. Kristof points to a new policy statement from the American Academy of Pediatrics based on an increasing wealth of scientific research: "toxic stress" in infancy or early childhood can "disrupt the architecture of the developing brain, thereby influencing behavioral, educational, economic and health outcomes decades and generations later".
Tumour and conscripted host cells produce matrix-degrading proteases that disrupt the architecture of surrounding tissue and release matrix-bound growth factors that support invasion.
The structures also highlight the mechanism by which A-strand Mabs disrupt the architecture of the mature virion, inducing premature fusion loop exposure and concomitant particle inactivation.
On the other hand, PDT may disrupt the architecture of CNV and help the antiangiogenic factor to affect the lesion more potently [ 21].
The structures reported also highlight the mechanism by which anti-A-strand mAbs disrupt the architecture of the mature virion, inducing dimer dissociation, premature fusion-loop exposure, and concomitant particle inactivation [ 40].
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Mutation of any of these tryptophans disrupts the architecture of the active site.
Cu deficiency disrupts the architecture of mitochondria, impairs respiration, and inhibits the activity of cytochrome c oxidase — the terminal, Cu-dependent respiratory complex (Complex IV) of the electron transport chain.
Acute alcohol administration significantly disrupted the architecture of tight junctions of the small intestine.
While the axoneme was disrupted, the architecture of the centriole was unchanged and a distinct cartwheel was present (Fig. 2BI, inset).
Peripheral sensory neuropathy is another prominent toxicity, thought to occur as a result of tubulin stabilisation disrupting the architecture of non-dividing neuronal cells.
As the disease progresses, the coalescence of these bumps of pigmented material appears on SD-OCT as thick and hyperreflective dome-shaped lesions that disrupts the architecture of the overlying outer retinal layers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com