Therefore, the versatility of camptothecin as a front line chemotherapy agent is increased because, in addition to inhibiting topoisomerase I, CPT is able to enhance apoptosis of cancer cells by disrupting survival signaling of the JAK/STAT pathway at the receptor level.
For the diseases caused by microbial pathogen, drugs usually are designed to inhibit the essential components of the pathogen to disrupt its survival.
Here, we demonstrate that expression of human wild-type tau is sufficient to disrupt the survival of dopaminergic neurons in a Drosophila model.
This study found that expression of human wild-type tau was sufficient to disrupt the survival of dopaminergic neurons in a Drosophila model and to cause a progressive impairment of motor and learning behaviours.
Without any essential pathways related to the mechanism of drug resistance, Ayati et al. applied balanced network bipartition method to discover the co-targets which separate interaction network into disconnected pieces to effectively disrupt the survival of a bacterium when it has multiple pathways to trigger the drug resistance [ 18].
Interfering with expression of EFNB3 in cancer cells can induce apoptosis and disrupt pro-survival networks (Stahl et al., 2013).
In this study we showed that the inhibition of N-linked glycosylation has the capability to affect ALK phosphorylation and disrupt pro-survival signaling associated to ALK, indicating that inhibition of this post-translational modification may be a promising therapeutic approach for ALK-depending NB patients.
Additionally, NMDAR overactivation also disrupts critical survival pathways by uncoupling synaptic NMDARs from cytoskeletal proteins and pro-survival signaling.
Consistent with these pathway models, we expect that targeting B in the context of deletion/downregulation of A could result in cancer-cell death by either disrupting both survival pathways (Fig. 7a) or by shutting off (forward) signals for cell survival (Fig. 7b).
Modulation of intracellular levels of iron (via chelation with deferoxamine (DFO)) also disrupts cell survival, implicating a need to critically monitor and maintain appropriate levels of cellular iron for cell survival.
