Sentence examples for disrupt sir from inspiring English sources

Although the local H3K79 methylation mediated by targeted Dot1 was able to disrupt Sir complex association [ 27, 32, 33], it was not sufficient to cause loss of telomere anchoring.

It is unlikely that the fusion with YFP disrupts SIR-2.1 function, because the same transgene can rescue the sir-2.1 0) sir-2.1 0.

The wedding disrupted by Sir Lancelot (John Cleese) was filmed in the courtyard and Great Hall.

Deleting the C-terminal domain of Rap1 therefore not only disrupts Sir-dependent silencing at telomeres but also abolishes Rif-protein inhibition of telomerase, and consequently, the net result is that telomeres become extremely long in a mutant lacking the Rap1 C-terminus (Kyrion et al., 1992).

As sir-2.2 and sir-2.3 are located less than one kilobase apart (wormbase.org), making it difficult to disrupt them simultaneously, we analyzed the triple-null mutants sir-2.1; sir-2.2; sir-2.4 and sir-2.1; sir-2.3; sir-2.4.

"I don't think if something has been done by Sir Alex Ferguson it's to disrupt anything, it's to give help and advice.

Alternatively, specific perturbations such as DNA replication may have disrupted the binding of Sir proteins to nucleosomes, thereby creating an opportunity for RNA polymerase to access heterochromatin.

That threat extended to the prestigious Cheltenham Gold Cup on March 18, but Sir Alex urged United fans in a statement on Friday not to disrupt the race.

Will he disrupt or be disrupted?

"They disrupt economic life.

Thugs disrupt their speeches.