Sentence examples for disrupt normal function from inspiring English sources

CHD4 mutations were all predicted to disrupt normal function of the protein, suggesting a functional role in the development of EC [ 15].

Although the modifications observed in the eutopic endometrium of endometriosis patients appear slight, they nevertheless affect sensitivity to PGE2 and PGF2 α and thus disrupt normal function.

To date, several synthetic-peptide-based inhibitors have been reported to be able to interfere with PB1 PB2 interactions and disrupt normal function of the polymerase 91, 92.

The remaining tumours that retain wild-type p53 develop alternative mechanisms that disrupt normal function and lead to malignant proliferation (Tovar et al, 2006).

All these lines of evidence point out BBP as an endocrine disrupting chemical, suggesting that it may interfere with the endocrine system and thus disrupt normal function in hormone-sensitive organs [ 10].

Using the transgene on a Mecp2 null background, we explored how the mutations disrupt normal function in RTT; using the transgene on a wild type background allowed us to explore whether the remaining functions of the mutant alleles can cause MECP2 duplication syndrome.

Since MAPK dependent pathways play a crucial role during pregnancy, non-physiological activation by Cd exposure may disrupt normal functions in trophoblast cells.

14 Since HSC70 is involved in autophagy pathways, notably in chaperone-mediated autophagy, 14 16– 18 leading to endogenous MHCII loading, we explored this mechanism, hypothesising that P140 might disrupt normal functions of HSC70 in this catabolic pathway.

Retrotransposition of X linked housekeeping genes to the autosomes, with subsequent acquisition of testis specific expression, is one mechanism by which such metabolic disadvantage can be corrected during spermatogenesis without disrupting normal function in somatic tissue[13].

Extrapolating back to FGFR4, we propose that the Glu681Lys mutation may alter the functional properties of the TK catalytic domain by reversing the charge of residue 681, potentially disrupting an ionic bond with residue Arg650, and thereby disrupting normal function of FGFR4 (Figure 5).

Sado and colleagues [ 27] observed significant upregulation of the Xist promoter in ES cells carrying a deletion of a large region including much of Xist exon 1 and some of Xist intron 1. Whilst it is possible that this deletion disrupts normal function of the intron 1 NOS and/or Tsix, it is also possible that other unidentified functional sequences have been removed.