Sentence examples for disrupt interaction from inspiring English sources

However, by analyzing GCP-WD mutations that disrupt interaction with Plk1 (S418A, T557A) and mutations in potential Plk1 phosphorylation sites (S433A, T487A) we find no evidence for defects in centrosome targeting.

Therefore, deletion of the Y79 residue is likely to disrupt interaction of RAB23 with effector proteins.

Previous work by Bronisz et al. suggested that M-CSF/RANKL combined signals disrupt interaction between Mitf and c-TAK1 in RAW264.7 cells (Bronisz et al. 2006).

Mutation of R504 inhibits IP3 binding (Yoshikawa et al., 1996) and is likewise expected to disrupt interaction of the 3 -phosphate of AdA.

Alternatively, targeted inhibitors that disrupt interaction between Mcm2-7 and other cellular proteins may be identified that specifically block abnormal DNA replication.

Patients with C-terminal CASK mutations also present with nystagmus and, strikingly, we show that these mutations specifically disrupt interaction with FRMD7.

Binding of receptor may also disrupt interactions of this hydrophobic region with neighbouring copies of UspA1 (akin to disruption of aggregation in the SAXS studies).

At 573 K the diffusivity of solvent molecules is sufficiently high to disrupt interactions.

We also outline strategies to determine whether mutations disrupt interactions with microtubule-associated proteins.

This has led us to suggest the hypothesis that these mutations may disrupt interactions between CBS and other proteins, which are important for its cellular functions.

Proteins function through interactions and mutations that disrupt interactions also change protein functions.