Although Group B sequences have a substitution in an important residue in EF-hand I, we show that one member of this group, MleiPP3, is a functional photoprotein, so it is likely that this substitution does not disrupt function in the other Group B proteins.
Because mutations that disrupt function are disfavored by natural selection, purifying selection leaves a detectable signature within functional elements; accordingly, this signal has been exploited for over a decade through the use of genomic comparisons of distantly related species.
Injuries to their avascular inner regions do not heal, disrupt function, and increase the risk for knee osteoarthritis.
The therapeutic use of corticosteroids (used in high doses in ESI) is potentially associated with a multitude of adverse effects that can disrupt function of the endocrine, cardiovascular, musculoskeletal, gastrointestinal, dermatologic, metabolic, and nervous systems (Manchikanti 2002).
Expression of this construct rescued a bah-1 mutation, indicating that the modification did not disrupt function.
C. pneumoniae has been shown to directly disrupt function of HIF-1a during infection of epithelial cells in vitro [30], which indicates that this lung pathogen may attempt to counteract the effects of A2b expression in actively infected cells.
