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We hypothesized that mutations in the accessory and catalytic subunits of pol γ would disrupt fast axonal transport.
Most mutations in Nav1.5 disrupt fast inactivation and thereby cause a persistent (or sustained) Na+ current.
These mutations mostly disrupt fast inactivation, thereby causing persistent sodium currents (Bennett et al., 1995).
Intraneuronal Aβ has been reported to disrupt fast axonal transport (FAT) in isolated axoplasms [ 50], to impair multi vesicular body (MVB) sorting by inhibition of the ubiquitin proteasome system [ 2] and to induce synaptic dysfunction leading to reduced PSD-95 and consequently GluR1 levels in synapses [ 3].
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BC will clearly invest in companies that can disrupt faster than the entertainment/media business can adapt, such as in digital delivery, gaming etc.
It's clear that the wider media business will go through profound change in the next few years and the new fund is positioned to invest in companies that can disrupt faster than the entertainment/media business can adapt.
Amazon's recent move into brick-and-mortar outlets suggests that technology and e-commerce may not be disrupting fast enough.
To confirm that accumulations of APP and synaptophysin represent disrupted fast axonal transport, we performed double labelling in ocular hypertensive rats that had been labelled with the neural tracer cholera toxin β-subunit (CTB).
The riot was set off by a power failure and water shortage that disrupted fast-breaking for the Islamic holy month of Ramadan, officials said.
Today, older, linear-thinking companies (think: the U.S. industrial-military complex) will become massively disrupted faster and faster.
Blockade of AMPA receptors may be expected to disrupt ionotropic fast excitatory signals to medium spiny neurons in medial shell.
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