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While it is important to continue to identify those environmental chemicals that disrupt development leading to birth defects, there must be an increased effort to develop criteria and assays that will capture the latent effects on long term development reflected by the DOHaD paradigm.
For example, viruses are ordinarily used to ferry in genes to activate pluripotency, but this foreign DNA integrates into the genome, and experts worry that it might disrupt development or cause cancer.
Any of these components might interfere with endogenous sterol-mediated signalling systems, and so disrupt development [30].
Here, we demonstrate that Slbp mutants, despite sufficient histones to support DNA replication, display several forms of genomic instability and cell cycle abnormalities that disrupt development.
In addition to the ddaC neurons, we found that mutations in CSN5 or nedd8 disrupt development of the DA sensory neurons of different classes, in particular ddaA, ddaB, ddaD, ddaE and ddaF neurons.
These chemicals can disrupt development and function of wildlife.
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A previous study from our group showed that significant pulmonary elevations of adenosine in ADA-deficient mice lead to inflammation and disrupted development (6).
Like many others over the years, it highlights the paranoia of the Chinese authorities and the security obstacles disrupting development of an international tourist industry in this stunningly beautiful, but impoverished region.
As suggested in this 2015 TechCrunch piece, it signals tech's potential role in disrupting development in Africa.
As suggested in this 2015 TechCrunch piece, it signals tech's potential role in disrupting development in Africa.
This decrease could account for poor circuit refinement [48] and as a consequence, for the disrupted development of orientation selectivity shown in Ethanol treated animals [9].
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