Sentence examples for disrupt core from inspiring English sources

We also provide a network view of disrupted pathways to show how copy number alteration can disrupt core pathways that are essential for cancer development and progression.

Several of the mouse mutants with craniorachischisis have mutations that disrupt core components of the PCP pathway, including Celsr1, Vangl1, Vangl2, Fzd3, Fzd6, Dvl1, Dvl2 and Dvl3 (Kibar et al., 2001; Murdoch et al., 2001a; Hamblet et al., 2002; Curtin et al., 2003; Wang et al., 2006a; Wang et al., 2006b; Merte et al., 2010; Andre et al., 2012).

As revealed in the group analyses, the regions that are activated in common by the patients most plausibly reflect, instead, those aspects of their sentence processing abilities that remain intact in the context of left hemisphere lesions that disrupt core syntactic function.

Balakrishnan, M. et al. Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells.

Last, approved anti-cancer drugs that inhibit AAK1 or GAK not only disrupt core-AP2M1 binding, but also significantly inhibit HCV assembly and infectious virus production.

Li, F. et al. PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.

A central issue of all analyses was the assessment of a realistic upper bound of energetics especially related to recriticalities in disrupted core configurations.

Importantly, physiological dysfunction is not driven by disrupted core clock function, nor by an internal desynchrony between organs, but rather the altered phase relationship between the internal clockwork and the external environment.

These studies identify the calcineurin/Rcan1-signaling cascade as a potential therapeutic target through which to benefit from innate circadian changes in cardiac protection without disrupting core circadian oscillations that are essential to cardiovascular, metabolic, and mental health.

In order to model the freezing behavior of molten metal of the postulated disrupted core in a CDA of an LMR and provide data for the verification of the safety analysis code, SIMMER-III, a series of fundamental experiments was performed to simulate the freezing behavior of molten metal during penetrating onto a metal structure.

A massive collision could warm Mars's mantle, disrupting core convection.