One loop conformation is unique to IgG4 and would disrupt binding, consistent with IgG4's anti-inflammatory properties.
For some people, their sleep could be disrupted by consistent grinding and clenching of their teeth.
Finally, the Sec61 RNAi phenotype was very severe, with extremely disrupted cells consistent with Sec61 as a major component of the ER translocon.
As presented in Figures 5(A) and 7(B)–(D), the inflamed choroid plexus has a highly disrupted morphology, consistent with previous reports in severe EAE (Engelhardt et al., 2001; Murugesan et al., 2012).
A disadvantage of these approaches is that all input trees must be rooted: given a set of trees covering variable sets of taxa, with potentially rampant LGT and variable rates of evolution disrupting any consistent pattern that might be expected, it is difficult to justify any rooting strategy that might be proposed.
This enhanced ability to disrupt biofilms is consistent with the improved solution-phase kinetics of the engineered enzyme, and may stem from a similar mechanistic origin.
This suggests that the mutations disrupt normal EXOSC3 function, consistent with a loss-of-function mechanism.
Interestingly, loss of H2A.Z deposition partially disrupted chromosome folding, consistent with a role for H2A.Z in CID formation.
The higher fraction of known cancer-causing genes in functional modules from our commonly disrupted pathways is consistent with our hypothesis that commonly disrupted pathways across many types of cancers would have many cancer "driver" genes.
Injection of ofd1 ATG MO (5 ng) or SPL6 MO (4 ng) disrupted normal patterns, consistent with randomization of situs, with excess right-sided, bilateral and absent expression (Fig. 4E G, Table 2 and data not shown).
