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Many mutations that disrupt components of this pathway affect the ability of larval worms to enter and leave the dauer stage, but they also increase the longevity and stress resistance of adults as well as reduce their fecundity [ 2- 6, 34].
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Repairing and restoring disrupted components in an enterprise data center requires a significant amount of time and human effort.
However, how fast and efficiently an enterprise infrastructure can be recovered depends on how the recovery mechanism restores the disrupted components, considering the inter-dependencies between services, along with the limitations of expert human operators.
Indeed, disrupting components in the niches may yield better outcomes without noncytotoxic effect, when compared with that of removing the CSCs [ 118].
In addition, disrupting components of the shelterin complex, including TPP1/POT1 and TRF2 (in combination with DNA repair factors involved in the classical non-homologous end joining [C-NHEJ], Ku70 and 53BP1) also results in elevated T-SCE [ 12- 14].
CNL is the most prominent mechanism of component disruption, with RBX1 being the most frequently disrupted component.
In addition, HL096PA1 contains two pseudogenes in the only predicted galactitol PTS [ 35] and one disrupted component in the single glucitol PTS.
To address this need, we disrupt cytoskeletal components in cell sheets to assess the effects of such disruption on cell sheet cohesion and contraction.
MV, O2, and IUGR inhibit alveolar and micro-vessel formation and disrupt matrix components in lung, resulting in reduced respiratory system compliance and increased airway resistance.
Releasing mechanisms that relate colony level information are then hypothesized to disrupt particular components of the priming mechanisms to trigger endocrinological cascades that lead to the next temporal caste.
Information-rich releasers (pheromones or other environment stimuli) are then hypothesized to disrupt specific components of the priming mechanisms to trigger endocrinological cascades that ultimately result in the activation of new priming mechanisms for generating the next caste-specific physiology.
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