Sentence examples for disrupt barriers from inspiring English sources

Xylan removal has been widely believed to disrupt barriers that hinder enzyme access to cellulose, but this research suggests that cellulase binding to xylan and, possibly, xylo-oligomers strongly reduces cellulase activity, and that xylan and xylo-oligomer removal or conversion to xylose can greatly reduce their inhibition.

Further, a small number of cells also die without getting extruded, which can disrupt barrier function.

In two independent studies, H. pylori strain SS1 was reported to disrupt barrier function in the gastric mucosa [ 41, 66].

Moreover, inhibition of IL-8 secretion by mutants unable to disrupt barrier function (e.g. eae-negative mutant) reveals that both processes are not linked.

This supported previous findings that the tir mutant does indeed disrupt barrier function and also suggested that Tir possesses a novel role to prevent undefined effectors from causing barrier dysfunction.

Pre-treatment of cells with jasplakinolide prevented WT EPEC from decreasing TER (P < 0.0001) but had little, if any impact on the ability of the tir mutant to disrupt barrier function (P = 0.472; Fig. 4).

We show that previous studies which suggest that a tir mutant does not disrupt barrier function (Muza-Moons et al., 2003; Miyake et al., 2005) are due to modified infection protocols that resulted in low moi that unknowingly extended a lag period associated with the tir mutant, thereby obscuring the strain's barrier disrupting activity.

In order to evaluate the ability of 17-AAG to reverse the effects of agents known to disrupt barrier function, culture medium was replaced with fresh EGM-2 containing the barrier disruptor, VEGF (50 ng/mL) in the absence or presence of 17-AAG (1 μM), and impedance was measured every 5 min at 15 kHz frequency.

Interestingly, the inability of the espG/orf3/tir triple mutant (which carries intact map, espF and eae genes) to disrupt barrier function implicates a critical role for Tir in the well-defined Map/EspF/Intimin-dependent barrier disruptive pathway (Dean and Kenny, 2004).

Given the absence of a strong inflammatory response in EPEC-infected humans, despite the pathogen's ability to disrupt barrier function, we examined the prediction that loss of barrier integrity does not lead to increases in flagellin-mediated IL-8 secretion.

These differences in the lung and plasma cytokine patterns suggest that in this model the cytokines were either locally produced or selectively transported, rather than passively moving from one compartment to the other through disrupted barriers.