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Another approach is to design new agents that disrupt adherence of the yeasts to host tissues and catheters.
Once confluence is achieved, trypsin and EDTA are used to disrupt adherence, and MSCs are re-plated within a larger number of flasks [ 30].
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Since a mutation in the Als5p amyloid-forming sequence disrupted adherence and aggregation on plastic, we hypothesized that the V326N and amyloid-forming Als5p peptides would also affect adhesion on polystyrene.
First, any form of movement during the three hours of mandatory inertia will disrupt the adherence of the injected CEnCs, and affect corneal thickness on the following day.
Disrupted attachment.
Bortezomib has been reported to alter the adherence of multiple myeloma cells to ECM proteins and bone marrow stromal cells [ 36], and to disrupt cell adhesion in spheroids derived from an ovarian cancer cell line [ 24].
Logistical issues at the systems, facility, and individual levels may also impede access and continuation, causing clients to unintentionally disrupt or discontinue contraceptive adherence.
Our suspicion is that this behaviour is related to low adherence; it is known that law adherence disrupts the effectivity of HAART treatments, (see, e.g. Conway, 2007).
To confirm the lines in which the genes PFB0106c, MAL7P1.172, PF14_0758, MAL7P1.171, PF10_0025, and PF13_0076 were disrupted had altered adherence properties, and to identify others in which adherence had been affected, we used flow based cytoadherence assays with CSA.
The type-IV secretion apparatus also injects the cag PAI-encoded protein CagA into the stomach's epithelial cells, where it disrupts the cytoskeleton, adherence to adjacent cells, intracellular signaling, cell polarity, and other cellular activities.
In the other temporal direction, depression may worsen glycemic control through physiological channels such as catecholaminic and noradrenergic mechanisms and/or behaviorally by disrupting patients' medical adherence and self-care routines (9).
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