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This may indicate, on a dual effect, the immediate vascular disrupting action of electroporation (increase in vascular permeability due to the disruption of endothelial cytoskeleton and endothelial cell swelling) and delayed effect due to the exposure of these cells to a high concentration of BLM causing endothelial cell death as observed in histological specimens.
In this work we examine the role of lateral phase separation in cholesterol-containing biomimetic membranes on the disrupting action of melittin using a label-free surface-sensitive technique, quartz crystal microbalance with dissipation monitoring (QCM-D).
Moreover, smooth (S) brucellae such as B. abortus and B. melitensis have OMs that are unusually resistant to the disrupting action of bactericidal peptides and complement.
All these changes are compatible with an endocrine disrupting action of BBP.
In our present study, we provide further evidence on previous observations about the tumour vascular disrupting action of electroporation.
In this study, we present a mathematical model of electric field distribution in tumour blood vessels, predicting vascular disrupting action of electrochemotherapy.
We have found that activation of the Rho/ROCK signalling pathway plays an important role in the vascular disrupting action of CA4P in vivo, which translates into necrosis induction in CA4P-responsive tumours.
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