First, we asked whether mouse transcripts orthologous to genes with increased expression in human psoriasis were disproportionately elevated in psoriasiform phenotypes, and conversely, whether mouse orthologues of psoriasis-decreased genes were disproportionately decreased in psoriasiform phenotypes.
IL-3 disproportionately decreased the turnover of transcripts annotated to the GO categories cell cycle (p<2×10−10), RNA processing (10−6), and other related categories.
In DBA males, transcripts associated with certain leukocyte populations were disproportionately decreased by HF diet (e.g., CD8+ T cells, B cells, DCs and Mφ), providing evidence that the diet had possible anti-inflammatory effects in mice of this strain and gender.
The fraction of cholinergic neurons and nerve fibres, however, was disproportionately decreased.
In tandem, refinements in the spliceosomal machinery could have increased splicing fidelity through eukaryotic evolution, disproportionately decreasing nonfunctional AS variants.
Additionally, fibrinolysis can be indicated by a normal R time and a disproportionately decreasing MA value over time.
Accordingly, Eisenhauer and Scheu (2008) found that earthworms disproportionately decreased the number and biomass of small-seeded plants establishing from seeds.
"While that wouldn't explain the disproportionate decrease percentage-wise, my instinct is that when jobs are harder to come by, it's minorities -- including women -- who are disproportionately impacted".
This disproportionately large decrease in Type II error is what one would expect from the removal of chimeric sequences joining two otherwise unrelated clusters.
The repercussions of fixing specificity at 90 95 % on sensitivity have to be interpreted more cautiously: given the relatively low number of true positives, a change in classification of an individual case from positive to negative may lead to a disproportionately large decrease in sensitivity.
