"It seems a little flat in here," he remarked at one point, pining for his nightly dose of "wildly disproportionate affirmation".
Long-term use can, according to Graham, lead to carpal tunnel syndrome (the compression of nerves in the wrists, which causes incessant tingling), raised blood sugar levels (which can trigger Type 2 diabetes), heart failure and – in excessive doses – gigantism, the disproportionate growth of body parts.
Specifically, the 60 nm SNPs were preferentially endocytosed by cells and, at high doses, caused a disproportionate decrease in cell viability.
About 2% of the world's population live above 3 km and receive a disproportionate 10% of the annual effective collective dose due to cosmic radiation, with a net contribution to effective dose by the neutron component which is 3 4 fold that at sea level.
The clinical importance of this nonlinear pattern is that dose escalation may result in a disproportionate increase in toxicity, whereas dose reduction may affect its efficacy [ 33, 90, 91, 94].
Plasma clearance of paclitaxel exhibits non-linear kinetics, which results in a disproportionate change in plasma concentration and area under the concentration time curve with dose alterations.
We assumed that methemoglobin reductase activity (k MR (t) ) is induced by methemoglobin rise to characterize the less-than-proportional increase in methemoglobin at higher nitrite doses, since lack of enzyme activity is known to result in disproportionate methemoglobin accumulation.
14 Moreover, due to phenytoin's zero-order (Michaelis-Menten) pharmacokinetics which result in a non-linear relationship between dose and subsequent serum levels, a small change in dose can result in a disproportionate increase in serum concentration.
This finding is probably due mainly to the fact that a disproportionate number of patients (more than one-third) in each of Groups B and C never received a dose of more than 250 mg m−2, and so were possibly underdosed.
