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Geography's fate in the Ivies, however, has also hinged on the activities of individual professors, the disposition of key administrators, trends within the discipline, and events outside the field itself.
This interaction can alter the disposition of key managers who control the health and social service infrastructure, by increasing their propensity to view local cooperative non-hierarchical action as effective and worthwhile to support.
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The peptide backbone of highly potent cyclic peptide-based CXCR4 antagonists was entirely replaced by an indole framework, which was expected to reproduce the disposition of the key pharmacophores consistent with those of potential bioactive conformations of the original peptides.
A molecular modeling study comparing the energy-minimized structures of resiniferatoxin and 35 demonstrated a good correlation in the spatial disposition of the corresponding key pharmacophores.
The development of a mechanistic understanding of the disposition of candidate drugs toward confident predictions of key properties associated with human drug absorption, metabolism, distribution, and excretion is critical.
Another group of phenes is related to functions and disposition of entities, and can be expressed using the has-function, function-of, has-disposition and disposition-of relations.
These transporters also play a key role in the disposition of therapeutic agents thus affecting their efficacy and safety profile.
Other key issues are the disposition of Iran's current nuclear stockpile (does it remain in Iran or not), its centrifuges (part of the "right to enrich") and its nuclear reactor.
Importantly, P-glycoprotein is also expressed in urothelial cells [ 19– 22], playing a key role in the disposition of chemotherapy in urothelial cancers [ 19, 21].
Elimination is one of the key processes in the disposition of chemicals, and it has a pronounced effect on the concentration−lipophilicity profiles.
Iranian elites, including Rouhani, view the disposition of 20-percent enriched uranium as Iran's key bargaining chip; the West won't defang this or other key threats without offering significant sanctions relief.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com