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The biphasic PAL plasma concentration time profiles could best be described by an open first-order disposition model with parallel fast (first-order) and slow (sequential zero-first-order) absorption.
Results Propofol pharmacokinetics was best described with a three-compartment disposition model.
A two-compartment linear disposition model was used.
This is the premise of the pseudo-equilibrium disposition model.
A recent publication used a three compartment disposition model for lumefantrine and a two compartment disposition model for desbutyl-lumefantrine [ 18].
Desbutyl-lumefantrine pharmacokinetics were described by a one compartment disposition model.
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One, two and three compartment disposition models were evaluated.
Both drugs were described satisfactorily by one compartment disposition models.
Artemether and dihydroartemisinin pharmacokinetics were described by one compartment disposition models.
Correspondingly, the development and assessment of i.v. disposition models provide a suitable basis to ensure simulations appropriately describe the processes of distribution, metabolism, and excretion within adults prior to predicting the contribution of such processes in pediatrics.
One- and two-compartment disposition models with first-order absorption and first-order elimination were evaluated based on the previous knowledge of the pharmacokinetic properties of the compound from a single-dose study.
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