There are numerous new methods of liposome preparation based on lipid drug interaction and liposome disposition mechanism including the inhibition of rapid clearance of liposome by controlling particle size, charge and surface hydration [126].
The findings in this investigation show that aminoglutethimide treatment influences oestrogen disposition by mechanisms unrelated to aromatase inhibition.
Total intestinal uptake of p-cresol can be considered a composite of intestinal generation (i.e., colonic microbial fermentation of tyrosine) and subsequent intestinal disposition, although mechanisms governing both processes are largely unexplored.
Prior knowledge about the metabolism, disposition and mechanism of bioactivation of a particular compound may allow prediction of the type of lung cell damage it is likely to produce.
He was also impressed with the patient's good disposition and coping mechanisms, which at the time he knew about only because of how Robert Pinnick, her primary-care physician, described her in his introductory letter.
Not only are the sites pinpointed where different classes of antibiotics inhibit protein synthesis, but their orientations, relative dispositions, and unique mechanisms of action are also revealed at the atomic level.
In a recent study, we have investigated the relationship between germ-line variants in genes encoding proteins involved in sunitinib disposition, metabolism and mechanism of action and the development of common toxicities, including haematological toxicities (van Erp et al, 2009).
According to the website, the factors affecting clinical response and drug exposure variability include adverse reaction risks, recommended dosing according to genotypes, drug targets, disposition genes, and drug mechanisms.
Taking into consideration a range of factors, she links the French "malaise" to "the ensemble of psychological and ideological mechanisms and dispositions that constitute the process of the transformation of experiences into well-being" — in other words, French culture.
The combined macro- and microscopic mechanism of disposition dictate the pharmacokinetics and overall pharmacodynamics and efficacy of the drug in the entire organ system.
