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The kinetics of drug disposition is described as a non-linear disposition function of drug structure and properties.
The in vivo absorption time profile was inferred by deconvolution of the observed plasma concentration time profiles against the unit disposition function (UDF).
(143) The term "disposition function" has been used in classical pharmacokinetics, 2074) in a sense similar to that illustrated by eq 6, but without the property variables.
One of the outcomes is the cell-QSAR approach, which extends, by incorporating the disposition function, conceptual 3D-QSAR techniques for the application to cell-level assay data.
The actual form of the disposition function is dependent on the complexity of the studied biosystem and on the properties of analyzed chemicals.
The kinetics of disposition is described as a nonlinear disposition function of the lipophilicity, acidity, reactivity, and 3D structure of chemicals.
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The construction of the disposition functions for various scenarios is described in the following parts, starting with simple cases, and gradually progressing to more-complex situations.
62 63 Specifically, we will collect outcome data across the following nine IMMPACT-recommended core outcome domains: (1) pain; (2) physical functioning; (3) emotional functioning; (4) participant ratings of improvement and satisfaction with treatment; (5) symptoms and adverse events; (6) participation disposition; (7) role functioning; (8) interpersonal functioning; and (9) sleep and fatigue.
(DJN VII.3.2) In fact, the choice appears to be prudential in nature, since certain forms of state may require specific human dispositions to function effectively (DJN VII.6.5), and some forms may be more suited for particular settings.
Using the distinguo [a refined distinction between similar qualities], Scudéry highlights the multiple gradations of a single virtue and how certain moral dispositions can function as either virtues or vices according to context.
Similarly, to describe missing, abnormal or additional dispositions and functions, a functional anatomy ontology should be developed.
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