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However, many studies have indicated that in childhood ALL, host variations in drug disposition determined by inherited genetic variants may, as frequently as truly resistant disease, lead to treatment failures [ 3].
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Intuitively, functions of biological entities establish the reason (or cause) that an entity exists (Wright, 1973) while their dispositions determine their capabilities and potentials (Lewis, 1997).
Disposition was determined using the South African Burn Society's criteria for referral to a burn centre (Table 1) [19].
Many potentially infected animals still remained in stores; their disposition was determined by individual states.
Discharge disposition was determined for all patients in the sample with no missing observations.
Health care systems that implemented electronic consultation or integrated eCRs often examined additional operational metrics related to specialty care access, such as time to first specialist response and patient disposition as determined by the specialist reviewer.
Many referral systems examined percentage of referrals completed electronically vs. fax/paper and patient disposition as determined by a referral management department, as well as unique scheduling metrics including the percentage of clinic template slots used for patients referred electronically rather than via paper or fax.
So at any given point, a system's behavioural dispositions are determined by its precise location in its phase space, and its current location in its phase space is a function of its previous locations.
The insulin secretion/insulin resistance (IS/IR) (disposition) index was determined by dividing ΔISR/ΔG by the severity of insulin resistance [ΔISR AUC 0 120/ΔG AUC 0 120 ÷ IR], as measured by the inverse of the Matsuda index (14).
If, however, quantitative information denoting the CLint (or Vmax and Km) and ontogeny of the specific transporter systems responsible for TS are available, age-dependent effects of transporter-mediated drug disposition can be determined using the equations previously described for scaling of hepatic processes.
Pancreatic β-cell function measured by the insulin secretion/insulin resistance (disposition) index was determined by dividing the ΔISR/Δglucose by the severity of insulin resistance (ΔISR [AUC] / ΔG [AUC] ÷ IR), as measured by the inverse of the Matsuda index (13).
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