Sentence examples for disposition and response from inspiring English sources

Safe and effective drug therapy in the elderly requires an understanding of both drug disposition and response in older individuals.

Collectively, these results suggest that the proximal promoter region of membrane transporters is rich in variation and that variants in these regions may play a role in interindividual variation in drug disposition and response.

Statistical analysis of pharmacokinetic data utilized a combination of approaches to assess the potential interactions between montelukast disposition and response.

Variation in drug disposition and response is associated with many anticancer agents, in part due to large inter-patient differences in pharmacokinetics (Petros and Evans, 2004).

When the roles of specific candidate genetic variations in drug disposition and response are known, randomized clinical trials to test for pharmacogenetic effects can be easily designed.

Taken together, these observations suggest that the autoantibodies can have three distinct effects on the receptor: (i) they modulate the binding of true ligands; (ii) they activate per se various effector pathways downstream of the receptor; (iii) they modulate the receptor's disposition and response to simultaneous agonist binding in a varied manner.

CES1 inhibition represents an overlooked and little studied source of variability in MPH disposition, tolerability, and response.

Older patients are generally at higher risk of adverse drug reactions due to age-related changes in physiology that affect drug disposition, metabolism, and response.

The approach to pain management in older patients may differ from that for younger patients, due to generally higher risk of adverse drug reactions from age-related changes in physiology that affect drug disposition, metabolism, and response [ 6].

Partly by the chance of his own disposition, and his response to fame, Roth anticipates the sensation of an impingement by the contemporary world on private experience in a way that makes him seem relevant to stuff I doubt he's even thinking about much directly.

Sensitivity analysis for the impact of total uptake transporter CL int,T on rosuvastatin disposition and PD response The automated sensitivity analysis option within the Simcyp Simulator was used to investigate the effect of total uptake transporter CLint,T on the plasma, liver, and muscle exposure to rosuvastatin and the change in PD response.