Human serum albumin displays time-dependent heme-based catalytic properties, representing a case for 'chronosteric effects'.
Ketolides and fluoroquinolones display concentration-dependent bacterial killing, and tetracyclines and macrolides display time-dependent killing.
The β-lactam antimicrobials display time-dependent bacterial killing with minimal to no persistent effects.
The NFs displayed time-dependent release ca. 80% of Sali in 4 days by a diffusion mechanism with remaining drug released from the NFs within 2 weeks upon initiation of nanofiber degradation.
Results: In the 12 of 15 surviving fetuses of group I, all constructs were found to resemble normal hyaline cartilage, engraft well despite their heterologous origin, and display time-dependent epithelialization derived from the native trachea.
A pyrrolo[3,2-d]pyrimidine-based type-II vascular endothelial growth factor receptor 2 (VEGFR2) kinase inhibitor, compound 20d, displayed time-dependent inhibition of the non-phosphorylated catalytic domain of VEGFR2.
In this series of compounds the bis-polyaminoacrylamide derivatives 2 4 were all shown to be competitive inhibitors, but only the bis-4-methyl-piperazin-1-yl-propylacrylamide derivative 4 displayed time-dependent activity.
It was shown that the mixture rays display time-dependent synergism, i.e. the range of synergistic effect narrows and the strength of synergism runs down with exposure time, which illustrates that the mixture toxicity of some chemicals is not a sum of individual toxicities at some exposure times and it is necessary to consider the toxicological interaction in mixtures.
Irreversible inhibitors display time-dependent inhibition and their potency therefore cannot be characterised by an IC50 value.
Furthermore, the photon emission intensity on the face and upper body appeared to display time-dependent changes.
HeLa cells stably expressing EGFP-BAG3 displayed time-dependent loss of the fusion protein, as well as endogenous BAG3 (Figure 1G).
