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The wildtype AKT displays significant increase in the kinase activity as compared to the Y176F mutant when coexpressed with either one of the Ack1 constructs, E346K and caAck (Fig. S5E and F).
In addition to the associations of gene expression with oncogenesis, we showed that the RUNX2 gene displays significant increase in expression in tumors with poor response to chemotherapy relative to the good responders.
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Note: R71C07 displays significant increases in both abdominal cleaning and leg rubbing.
An aberrant increase in basal cell proliferation was observed at P28, when prostatic tissue displays significant increases in growth in response to androgen levels (1, 6).
Hence we were able to design and synthesize compounds that displayed significant increase in efficacy as EPIs against AcrB.
However, TTC9A−/− female mice displayed significant increase in immobility (t(18) = −3.342, p = 0.004) and time-spent in the corner zone (t(16) = −2.867, p = 0.011) compared to the TTC9A+/+ mice (Fig. 4C,F), indicating anxiogenic response.
Numerical examples display significant increase in the number of cycles corresponding to crack initiation phase in comparison to traditional (regular) notch shapes.
Immobilized biocatalyst displayed significant increase in thermostability at 60 and 65 °C.
Table 3 lists metabolite pairs that display significant increase in the strength of association when using ratios (p-gain>241), thereby indicating that these metabolite pairs are possibly linked through some diabetes-related metabolic or regulatory process.
PB-Ack1 transgenic mice (TG) display significant increase in AKT Tyr176-phosphorylation leading to Ser473/Thr308-phosphorylation (Fig. 5C, top 3 panels) and AKT substrate FOXO3a Ser318/321-phosphorylation (Fig. 5B, panel 2) in the prostates.
[mean SEM ]: The AD fed group displayed significant increase in body weight (after 90 days; p < 0.01).
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