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The fragment view also displays mutations extracted by the text mining process.
Mitochondrial DNA is relatively more vulnerable to damage and displays mutations at a 10- to 50-fold higher rate compared to the nuclear genome [ 20, 21].
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Each database relies on both medical and molecular expertise, and uniquely displays mutation and clinical information together.
To redress this imbalance COSMIC now displays mutation data that we have generated from known cancer genes in the NCI-60 cell line panel of 59 lines and a further 669 cancer cell lines (http://www.sanger.ac.uk/genetics/CGP/CellLines/).sanger.ac.uk/genetics/CGP/CellLines/
Here, we show at the pathway level that the majority of the insulinomas display mutations, copy number variants and/or dysregulation of epigenetic modifying genes, most prominently in the polycomb and trithorax families.
Up to 60% of BRCA1 mutation-associated ovarian tumors also display mutations in the p53 tumor suppressor gene [25], [26].
However, disorders displaying mutations in the cohesin network termed cohesinopathies do not show severe defects in sister chromatid cohesion [14], [23], [24], [25].
Mucinous lesions displayed mutations most frequently.
None of them displayed mutations in KIT or PDGFRA.
All of the 16 investigated strains displayed mutations possibly associated with high-level FQ resistance.
Sequence comparison shows that these important regions display mutations in RPSAP8 but are conserved in RPSAP9.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com