Thus, although our results confirm that different tumor cell lines display marked differences in how they respond to autophagy inhibition, these differences can occur irrespective of RAS mutation status and, in different contexts, can either promote or reduce chloroquine sensitivity of tumor cells.
Different isoforms of enzymes can display marked differences in their kinetics and especially in their substrate specificities, as well as in the tissue or developmental stage dependent control of their expression levels or response to stimuli [ 29].
High-frequency clastic shelf sequences deposited in high-latitude settings display marked differences, in term of facies and stratigraphic architecture, with respect to their lower latitude counterparts.
Our results further reveal that the two-disulfide variant proteins, while possessing the same global fold as the wild-type, display marked differences in their folding pathway in particular, the absence of a characteristic α-helix to β-sheet transition, which is a fundamental feature associated with misfolding of proteins into amyloid fibrils, especially in the context of prion diseases.
Thus, it can be clear that the Abs of the three photoelectrodes shows relatively small differences, but the spatial distributions of photogenerated carriers display marked differences.
The volcanic Chilean soil and the clastic Turkish clay examined in these studies display marked differences themselves, although the presence swelling clays and calcareous minerals was noted in both.
