It displays dose-dependent efficacy in numerous pharmacodynamic (PD) assays that measure potential for anti-psychotic activity and cognitive improvement.
As shown in Figure 7b, conjugate 1b displays dose-dependent target knockdown while the control siRNA conjugate 5 does not show activity.
Ghrelin, an endogenous ligand for the growth hormone (GH) secretagogue receptor, displays dose-dependent GH-releasing activity (Kojima et al, 1999).
Stomatin displays dose-related effects upon ASICs (Price et al, 2004) and upon transfection of stomatin with ASIC3, we also observed proton-gated currents of varying amplitudes.
For example, Table 3 displays dosing regions built for several ampicillin indications based on different patient scenarios.
The visualizations employ region boundary surfaces to display anatomy, polygonal meshes to display treatment beams, and isovalue contour surfaces to display dose.
When a small amount of GEN is added, TMP displayed dose dependent inhibitions on the bacterial growth.
Softening displayed dose dependent response, with lower concentrations of propylene showing reduced softening.
Chemical effects generally increase with greater exposure, but hormones rarely display dose linearity.
All the three fractions displayed dose dependent significant (P < 0.001) antiplasmodial activity as compared to the control.
