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As a counterexample, it was found that in incompatible crosses of Drosophila simulans, the percentage of embryos displaying defects during the first cell cycle corresponded exactly to the CI level [28].
Accordingly, Afg3l2 haploinsufficient mice recapitulate most features of SCA28 patients, displaying defects in motor coordination and balance due to dark degeneration of Purkinje cells (PC-DCD) (14).
In addition, nab3 mutants shared overlapping phenotypes with esa1 mutants, displaying defects in rDNA silencing, cell-cycle progression, and the DNA damage response.
In keeping with a lack of effect of sir2 mutation on centromeric heterochromatin maintenance, we saw little evidence of sir2Δ cells displaying defects in chromosome segregation when cells were assessed for chromosome segregation defects during anaphase (Supplementary Figure S1).
In normal adult tissues, CXCR4 and CXCL12 are constitutively expressed in a wide range of tissue [ 20– 22], and mice lacking CXCR4 die in utero or shortly after birth displaying defects in the hematopoietic and nervous systems [ 23].
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Mammalian cells with defective HCF-1 also display defects in mitotic H3S10P status.
Of course in so doing we have again to use ordinary words, and these may display defects similar to those which the elucidations are intended to remove.
To determine whether malignant cholangiocytes display defects in CD40 mediated apoptosis.
Moreover, gain-of-function mutants of Hh signaling displayed defects in body wall formation (Fig. 6F,J).
85 100% Ppt1RNAi-elav-Gal4 embryos display defects ranging from mild to severe axon bundles (Figure 5C and D; Table 4).
Moreover, both avian and mammalian myotubes displayed defects in sarcomere assembly, a specific trait of the fully differentiated phenotype.
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