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Competitive binding assays based on the lectin Concanavalin A (ConA) have displayed significant potential to serve in continuous glucose monitoring applications.
Refractory complex concentrated alloys (RCCAs) represent an emerging class of materials that have displayed significant potential for increased mechanical performance at extreme temperatures over conventional refractory alloys and Ni-base superalloys.
FRF displayed significant potential in terms of increasing intracellular calcium and cAMP levels even in presence of a phosphodiesterase inhibitor, IBMX in cultured pancreatic islets.
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In particular, concentrated solar power technologies are displaying significant potential for electricity production.
While MSCs display significant potential in tissue engineering and therapeutic applications, the regulatory mechanisms underlying the differentiation of these cells are yet to be established.
The BPMS displays significant potential as an effective, inexpensive system for small wind turbine manufacturers to ensure the reliability of their pitch regulating over-speed protection mechanisms.
Furthermore, MOFs derivates display significant potential when they are used in electrocatalysis and electrochemical energy storage owing to their porous structure, ultra-small active materials, and homogeneously conductive carbon scaffold.
Screening of synthetic analogues has identified compounds that display significant potential as preventive and therapeutic anticancer agents (reviewed in Altucci and Gronemeyer, 2001; Fontana and Rishi, 2002; Hammond et al, 2002; Ortiz et al, 2002; Sun and Lotan, 2002).
The compound (4u) displayed significant inhibitory potential with MIC 25 μg/mL against P. mirabilis, P. vulgarise and threshold activity against B. megaterium, and E. coli with MIC 120 175 μg/mL, it may have a basic moiety of the bromo pyridine group.
Biological assay unveiled that, compounds A-1 to A-6, B-1 to B-4 and C-1 to C-3 disignificantninhibitoryhibitory potential against THP-1, COLO-205 and HCT-116 cell lines which were more sensitive towards the designed hybrids.
Notably, compounds 34 and 38 appeared as most active multifunctional agents in the entire series and exhibited excellent inhibition against AChE (IC50 = 0.048 μM: 34; 0.036 μM: 38), Aβ aggregation (max% inhibition 82.2%, IC50 = 9.2 μM: 34; max% inhibition 80.9%, IC50 = 10.11 μM: 38) and displayed significant antioxidant potential in ORAC-FL assay.
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