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These compounds also displayed selectivity for ERα over ERβ.
Unlike many PI3Kα/mTOR dual inhibitors, our compounds displayed selectivity for PI3Kα.
Among these five supports, only TiO2-supported catalysts displayed selectivity for 1-naphthol hydrogenation towards 1,2,3,4-THNol 1,2,3,4-THNol
The best pharmacological profile was obtained for the compound 4b, which displayed selectivity for increasing the force of contraction (46±3%3% change over the control) rather than the frequency rate (16 ± 4% change over the control) at 100 μM.
It is unclear why compound 7 displayed selectivity for TbNMT over hNMT (Table 1).
The GD17-20 trelicitedelargerd largeffectscthathat displayed selectivity for regions with 5HT nerve terminals and that were preferential for males.
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We identified a number of potent inhibitors that display selectivity for endogenous cathepsin targets both in vitro and in vivo.
Rpn10 (also called PMSD5 and S5A) contains two Ub-interacting motifs (UIMs), which display selectivity for longer poly-Ub chains (Young et al., 1998; Glickman et al., 2009).
The results demonstrate that these alkaloids are nAChRs antagonists, with tetrandrine and hernandezine displaying selectivity for one of the major neuronal subtype, the α7 nAChR.
The results of these initial studies are reported herein, and a structure which displays selectivity for As III) over As V) and other anions has been identified.
A combination of rational design based on mimicking natural protein carbohydrate interactions and solid-phase combinatorial chemistry has led to the identification of an affinity ligand which displays selectivity for the mannose moiety of glycoproteins.
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