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Interestingly, Mst1−/− T cells displayed reduced levels of FoxO3a and FoxO1 proteins, and the phosphorylated form of FoxO1/3 (Figures 1B and S5).
Second, only R6/1 males displayed reduced levels of social affiliation, an effect that was observed independently of the type of social stimulus employed.
By immunoblot analysis, compared to tg mice infused with vehicle alone, α-syn tg mice that received intra-cerebral infusions with rapamycin displayed reduced levels of α-syn in the membrane fraction with a concomitant increase in the lysosomal fraction (Figure 8O, P).
Plants carrying PAD4 mutations displayed reduced levels of SA, decreased expression of the defense gene PR1, and reduced synthesis of the indole derivative, camalexin, after infection with a virulent strain of Pseudomonas syringae[ 7- 10].
Like ESCs, these human iPSCs also displayed reduced levels of oxidative stress, decreased amounts of intracellular ATP, and increased production of lactate.
Virus in SELP 815K had greater efficacy of tumor suppression, promoted greater levels and greater duration of viral gene expression, and displayed reduced levels of injection site toxicity.
Carcinoma samples displaying reduced levels of MCT1 were found to express the high affinity glucose transporter, GLUT1, suggesting that there is a switch from butyrate to glucose as an energy source in colonic epithelia during transition to malignancy.
HFD L2AKO livers also displayed decreased levels of Atg5/12, accumulation of p62 (Fig. 4J) and decreased turnover of ubiquitinated proteins in lysosomes (Fig. 4K), all pointing to reduced degradation via macroautophagy under these conditions.
Different point mutants analyzed displayed various reduced levels of dNADH-K3Fe CN 6 dNADH-K3Fe CN 6ity.
Accordingly, MEKK1-deficient mice display decreased levels of uPA, which result in reduced levels of activated plasminogen and impaired tumor cell migration and invasiveness [ 53].
As Additional file 5: Table S1 indicated, these PR genes displayed a reduced level of expression at 72 HPI in APIP12-KD mutant.
