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Of particular interest in this previous study [ 26] was the observation that the cells were not only growth inhibited in response to mifepristone, but that they also displayed major changes in their morphological features.
In a previous study we made the serendipitous observation that when cancer cells of various tissues of origin were exposed to concentrations of mifepristone that inhibited their growth [ 26], the cells displayed major changes in shape when compared to untreated growing cells.
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Moreover, the mice display major changes in membrane biophysical properties.
Two others appear linked to C-terminal ends of super families of protein genes/pseudogenes, but these genes display major changes in amino acid sequence and peptide chain length.
The present findings clearly demonstrate that Tc1 mice display major changes in novelty-driven spontaneous activity characterized by spontaneous hyperlocomotion, abnormal exploratory behaviour and impaired habituation to the test environment.
However, scientific opinion articles displayed major temporal changes in the positive-to-negative effect ratio following regulatory warnings, showing more negative-effect articles.
Previous studies indicated that the MF-to-CA3 pyramid synapses in the hippocampus displayed major structural changes but retained functional characteristics following genetic ablation of synapsins I and/or II (Spillane et al. 1995; Takei et al. 1995).
Classically these metabolites are identified by either mutant screens or looking for metabolites which display a major change in concentration.
Both groups displayed major shifts in BCC upon dietary shifts, including dietary shifts that both did and did not change milk fat production.
The fossil diatom and geochemical sediment analyses display three phases that represent major changes in the lake development: (i) a marshy phase (ca. 16.6 10 cal. kyr BP); (ii) a brackish water lagoon phase (ca. 10 6.6 cal. kyr BP); and (iii) a freshwater lake phase (since ca. 6.6 cal. kyr BP).
The results displayed in Figure 7 reveal that over 86% of probes changing in T1X2B also underwent major changes in T1X2A, and over 64% of changes were common between all three PDXs originating from T1P.
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