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Control subjects and mild PD subjects displayed impairment in movement element scores in the absence of visual feedback.
Haploinsufficiency of COUP-TFII also displayed impairment of white adipose tissue development and reduced body fat mass.
Because DMSXL mice displayed impairment in respiratory function, these mice present a useful tool for investigating the pathological changes underlying the respiratory failure associated with DM1 disease.
In one widely cited randomized trial of Lucas et al. [ 82], patients receiving very high hyperoncotic albumin doses (1,142 g) and total fluid volumes (44.9 l) displayed impairment in pulmonary function.
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As adults, rats exposed to the low-intensity (30 50 nT) complex magnetic field displayed impairments in contextual fear learning and showed anomalies in the cytological and morphological development of the hippocampus.
Rats exposed for 30 min before but not 30 min after hourly training sessions for spatial memory displayed impairments comparable to those elicited by complete electrode-induced saturation of hippocampal activity.
The biomechanical measurements of reaching showed that the advanced PD subjects were more impaired than were the control groups, but both mild and advanced PD groups displayed impairments in elements of the reach movement, especially in aiming, rotation of the limb, and grasping.
These mice also displayed impairments in motor coordination.
Furthermore, homozygous CBKO mice displayed impairments in motor coordination and activity.
The problem gamblers and alcohol-dependent groups displayed impairments in risky decision-making and cognitive impulsivity relative to controls.
The advanced PD group did, however, display impairment in the visual control of reaching in that they tended to fixate the target both before reach initiation and after grasping and this deficit was ameliorated by music.
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