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Ectopically expressed Tau*C2A and Tau*S2A displayed dramatically reduced levels of toxicity in fly eyes in comparison to Tau*.
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In addition, KO mice displayed dramatically reduced bicarbonate levels (CO2) in blood (p = 0.006) indicative of serious disturbance in the acid/base balance compatible with metabolic acidosis.
Consistent with the important role of the LIM kinases in regulating cytoskeletal structure, treated cells displayed dramatically reduced F-actin content.
Other regions displayed dramatically reduced frequencies.
Consistent with this result, these cells displayed dramatically reduced transcriptional activity at 33°C against the HSE4Ptt-CYC1-LacZ reporter (Figure 3A).
As can be observed in Figure 4, the red pulp displayed dramatically reduced cellularity, although hematopoietic cells of all series appear to be present.
All of the compounds displayed dramatically reduced potency, suggesting that the 5-amino group may make an additional hydrogen bond to the kinase hinge.
However and somewhat surprisingly, dramatically reduced levels of AtHscB also results in relatively specific phenotypic consequences.
All three SSc fibroblast lines showed dramatically reduced levels of nuclear PPAR-γ compared to healthy control fibroblasts (Fig. 2B).
Elimination of RGS7 dramatically reduced levels of Gβ5 and R7BP in the hippocampus.
It was shown previously that loss of NF-L in sciatic nerves dramatically reduces levels of axonal peripherin [28].
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