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The mutants lacking the first 252 residues or residues 232 252 displayed compromised ATPase, protein degradation and ATP-dependent peptide translocation abilities but retained WT-like steady-state peptidase activity.
The ATR HCT 116 cells also displayed compromised activation of Chk1, an important downstream target for ATR.
In support of the significance of our finding, several animal models with aberrant profilaggrin/filaggrin processing displayed compromised epidermal barrier function [45], [46], [47], and skin disorders in humans including ichthyosis vulgaris and atopic dermatitis are associated with null mutations within the FLG gene [44].
Lymph nodes were evaluated in these tumors samples: 41 (56.9%) displayed compromised lymph nodes.
(simw ); Aatm Ore displayed compromised Complex I and IV activity (Complex I P ANOVA<6e-5, and Complex IV P ANOVA<0.01) (Fig. 5B, supplementary material Table S7).
GFAP/vimentin-knockouts displayed compromised astrocytic function with attenuated reactive gliosis, but no obvious alteration in the in vitro activation of hepatic stellate cells despite the lack of IF network (Geerts et al. 2001; Pekny and Pekna 2004).
Similar(52)
Here we reveal for the first time that wild-type E. coli displays metabolic heterogeneity following sustained periods of N starvation, with the metabolically active population displaying compromised viability.
Instead we found that that BiP3 ox/Nat XA21 double transgenic plants display compromised XA21-mediated resistance.
Despite this, the enlarged synapses of highwire mutants display compromised synaptic function which is contrary to what we found when overexpressing Rheb, so Highwire is likely to have multiple functions at the synapse besides simply the regulation of Tsc.
LET-363 is involved in the dietary restriction response induced by mutations in either eat-2 which lead to reduced food intake by impaired pharyngeal pumping [8], or in pep-2 mutants which display compromised intestinal uptake of dietary peptides [9].
Functional studies have shown that yeast mutants lacking Hmt1 display compromised intracellular protein trafficking, aberrant messenger ribonucleoprotein particle (mRNP) formation and defective silent chromatin formation [ 9, 11, 14].
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