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In accordance with data of caspase-9 inhibition, HeLa cells expressing Gadd45 α siRNA and infected with M90T displayed a strong decrease in caspase-3 activity and a significant reduction of DNA fragmentation.
The two independent IVSmut transgenic lines, in which MIR163 had both 5′ and 3′ splice sites mutated, displayed a strong decrease in miR163 accumulation (16 17% of wt level) associated with a strong decrease in pri-miR163 levels (12 14% of wt level; Fig 2B).
Dendrites that were chosen from plaque-free overview images (>100 µm from plaques, supplementary Figure 1a) did not show spine loss (0.36 ± 0.01 spines/µm, Fig. 1b), but the ones that were in close proximity to plaques (<30 µm from plaques, supplementary Figure 1b) displayed a strong decrease in spine density (0.27 ± 0.02 spines/µm, Fig. 1b).
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Lastly, DG C and DG GP exhibited high r values between close markers, displaying a strong decrease with distance, with a faster decrease in C than in GP.
Immunocytochemistry on cardiac fibroblasts displayed a strong reduction in type I collagen staining in both Aga2 severe cells and ECM (Fig. 2A), and a slight decrease in collagen staining in Aga2 mild cells.
While the results obtained for the mussel B. thermophilus seem to indicate a metabolic depression (strong decrease in the level of mRNA expression of numerous genes) when temperature increased, the annelid P. pandorae mainly displayed a strong regulation of the mRNA encoding subunits and linkers of respiratory pigments and some proteins involved in membrane structure.
Furthermore, PTEN and pAkt expression also displayed a strong association (RR = 0.55, 95% CI 0.41 0.74, P = 0.00008; data not shown) showing that there is a decreased likelihood of being PTEN negative when expressing high levels of pAkt.
PL spectroscopy confirmed that the synthesized composites displayed a strong eye-visible green light emission.
Secondly, the side heteroaromates displayed a strong effect on the cytotoxicity and selectivity towards cancer cells.
In contrast, these cells displayed a strong cytoplasmic immunoreactivity at the light microscopical level.
The enzyme displayed a strong product inhibition by ADP.
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