Results from Fig. 4B displayed a reduced responsiveness to both NE and ISO in cardiomyocytes from APP/PS1 mice compared with those from WT group.
Remarkably, in the current investigation also TLR2 KO mice displayed a reduced responsiveness to PLN and this attenuated phenotype was not much different from that of TLR4 KO mice.
Arterioles in rats exposed to 0.1 mg TiO2 or ROFA displayed an attenuated responsiveness to A23187 infusion.
In agreement with observed differences between the stages and diagnostic sensitivity, the BIS R0 displayed a considerably better responsiveness.
All schools displayed a degree of responsiveness to the changing situation, but some members of school communities interpreted the policy and procedure shifts as inconsistent and unresponsive to local circumstances.
Despite their impaired DDR, CD8+CD28− T cells display a high responsiveness to the homeostatic cytokine IL-15 (Alves et al., 2003), which increases survival, rescues T-cell proliferation via the PI3K/AKT/GSK3 signaling pathway, increases anti-oxidant capacity, and improves the quality of antigen-driven responses (Alonso-Arias et al., 2011; Kaur et al., 2011).
While in various circumstances the mesenteric veins display a greater responsiveness to contractile stimuli than the corresponding arteries [ 5, 21], this difference should be attributed to the specificity of the neuroeffector coupling, or to signal transduction mechanisms underlying the functional distinctions between capacitative and resistive regions of the mesenteric circulation.
The conduit arteries from diabetic rats also displayed a significant loss of responsiveness to phenylephrine.
Compared to mechanical stimulation of the noninjected arm, subjects displayed a significant increase in responsiveness to punctate stimulation at the lateral border of the flare area (P < 0.05).
In the behavioral paradigm, the HMF chicks had a higher elimination rate than the GMF chicks and displayed a significant reduction in overall responsiveness.
