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Previous approaches targeted a binding pocket where derivatives of ligands displayed a defined structure-activity relationship.
Many of these endogenous molecules displayed a defined localization that correlated to specific tissue compartments (Fig. 4 C, D) while other compounds were more ubiquitously expressed throughout the tissue sample (Fig. 4 B, E).
Analysis of cell morphology over 30 s showed that ∼70% of control peptide and untreated cells displayed a defined leading edge comprising lamella and lamellipodium, whereas 50% of the β2-actinin peptide-treated cells had no definite leading edge, and a further 10% showed minimal lamellipodial extension.
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Moreover, this interaction displays a defined upstream-downstream hierarchy of DSs, which can also be observed in Fig. 1.
In our own studies, we previously demonstrated that EMT-6 tumors display a defined level of hypoxia-driven uptake of [F]FAZA [ 47].
In addition, we demonstrate that Fucα(1−2 Gal sugars are highly enriched in the developing OB and display a defined spatiotemporal organization that is regulated by FUT1.
In addition to the spatio-temporal dependence of the MECP2 expression, the brain contains a heterogeneous cell population, including both low MeCP2-expressing cells (MeCP2lo) and high MeCP2-expressing cells (MeCP2hi), displaying a defined distribution pattern.
The wet membrane of S-PFSO2NH-GCI-OH S-PFSO2NH-GCI-OH S-PFSO2NH-GCI-OH S-PFSO2NH-GCI-OHcture with the ionic cluster displayed of 4–5 nm.
All of the six groups displayed a clearly defined and consistent hierarchy over 7 days of observations.
The transcription of PFI1785w displayed a clearly defined profile, similar to that of var2csa, suggesting a specific association with placental parasites.
Further, girls from valley towns displayed a poorly defined relationship between breast size and mammary gland development, whereas girls from the Yaqui foothills, where traditional ranching occurs, show a robust positive relationship between breast size and mammary size.
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