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(2017) present multi-conformer analyses from room temperature X-ray data of two ubiquitin phage display variants binding deubiquitinase USP7.
For example, VIKING filtering to display variants with: (1) an ACMG-type pathogenicity category of 1 3; (2) an allele frequency of less than 0.1 %; (3) that fit a recessive inheritance pattern (homozygous, compound heterozygous, or hemizygous); and (4) that are in OMIM monogenic disease-associated genes, yielded 16 variants in eight genes in WGS18 of sample UDT_103 (Additional file 2: Figure S2).
The number of SNPs in ImmPort genes did not differ significantly from the average number in the re-samplings (p = 0.22) and the empirical probability of obtaining 246 genes with at least one significant SNP resulted equal to 0.041, indicating that immune response genes more frequently display variants correlating with helminth diversity compared to randomly chosen loci.
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Pulling apart the two helices up to 3.00 nm from each other, potentials of mean force were calculated by umbrella sampling with a view to compare the energy barriers of the mother dimer to the phage display variant.
Again, this individual did not display variant viruses within their viral population.
However, clonal regenerant animals display variant phenotypes caused by defective epigenetic reprogramming of gene expression [ 2], and clonal regenerant plants exhibit poorly understood heritable phenotypic ("somaclonal") variation [ 4 7].
We propose that in cancer, a change in primary transcript expression at miRNA loci provides an important first step in the identification of those miRNAs that display variant epigenetic marks.
In addition, three loci, D13S317, D5S818, and D7S820, displayed variants adjacent to the core repeats and caused discordances between sequence-based and length-based typing results.
The only gene with more than two families displaying variants was KIAA0586, prompting further analysis.
These thieno[3,2-c]pyridin-4-amine derivatives displayed variant inhibitory activities against BTK in vitro.
In this paper, twenty one compounds displayed variant inhibitory activities against BTK in vitro, and compound 14g showed the most potent inhibitory activity against BTK enzyme, with the IC50 value of 12.8 nM.
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