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Increasing studies have shown that CSCs display treatment resistance to chemotherapy and radiation therapy [4]-[6],[25], while clinical neoadjuvant chemotherapy expanded the proportion of CSCs [20],[20].
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Moreover, 23 genes displayed treatment by time interactions (Additional file 4).
Table 4 displays treatment recommendations and a summary of barriers to recovery.
As a result of this survey, 6,266 and 15,575 genes displayed treatment main effects and time main effects, respectively.
Another presentation of the data displays treatment outcomes based on final visual improvement according to pretreatment visual acuity.
Between the three gene sets some overlap was identified: 15 genes were present in all data sets representing 65% (15/23) of the genes that displayed treatment by time interactions.
Table 3 displays treatment-related AE.
This information should help conservators to estimate the risks involved during display, handling, and conservation treatments.
Fig. 2 Visual display of treatment and control areas.
Resting tumor cells display enhanced treatment resistance compared with actively cycling tumor cells, as several groups of anticancer drugs directly target the active cell cycle.
30 Therefore, it is reasonable to assume that patients treated with either drug will display similar treatment costs and resource use due to adverse events.
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