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The used (paper-based) protocol was often not extensively tested before implementation, and adherence to it was not reported or registered, a fact that may be especially problematic in a multi-center approach where different sites often display substantial differences in standards of critical care including important aspects in nutrition and glycemic control.
These data further support the notion that closely related hybrid TCRs can display substantial differences in fine specificity.
Cupriavidus metallidurans strains do display substantial differences in the diversity and size of their mobile gene pool, which may be extensive in some (including the type strain) while marginal in others.
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The real precursors generally display substantial difference in the nature of folding (as well as in MFE) from their shuffled counterparts [ 16].
It was demonstrated that the 21 Arabidopsis ASK proteins displayed substantial differences in their abilities to interact with different F-box proteins and that ASK1, ASK2, ASK11 and ASK12 could interact with COI1, FKF1, UFO and other F-box proteins.
The sera displayed substantial differences in their protective effect (Fig. 6).
For instance, mature SNc dopaminergic neurons can generate regular tonic activity patterns of similar frequencies while displaying substantial differences in the amplitude and gating properties of IA and IH (Amendola et al., 2012).
These reports show substantial differences in their results.
The heat map strikingly illustrates that diversity is non-uniform, with genomes in some clusters (e.g., Subclusters B1, C1) being very closely related, whereas in others they display substantial differences (e.g., Subclusters A1, F1).
They also display substantial differences with each other, such as their codon usage, the nature and origin of their CRISPRs systems and the genes possibly involved in particular environmental adaptations.
The ribosomal DNA sequences display a substantial difference in evolutionary rates among and within the genes (from fast-evolving mitochondrial to the much more conserved nuclear rDNA), and are easily amplifiable due to the presence of multiple copies per genome and the pattern of concerted evolution [ 33].
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