Sentence examples for display potency from inspiring English sources

While our previously studied sulfoximine-based inhibitors display potency of 2.5 nM (IC50) against HIV-1 protease, introduction of the sulfoximine moiety into the asymmetric Indinavir yielded only micromolar inhibition.

The strong focus on the sizes of Aβ assemblies that display potency in the disruption of neuronal function may falsely give the impression that other structural aspects, like peptide conformation, are being neglected.

In addition, by exclusively considering high-confidence activity data, it has been found that the most promiscuous bioactive compounds interact with two to five targets from the same target family, are predominantly active in sub-µM range, and display potency differences within one or two orders of magnitude against their targets.

These efforts led to the identification of novel αVβ3 inhibitors displaying potency in the subnanomolar range, selectivity versus αIIbβ3 and functional efficacy in relevant cellular assays.

Results of biological studies revealed that the majority of compounds exhibited potent to moderately potent activity and among them, 12 displayed potency comparable to that of the imipramine with %DID of 37.95 and 44.84 in the FST and TST, respectively.

The primary antimycobacterial screening reveals that mono-indolizine mono-salts are displaying potency superior to the second-line antitubercular drugs Cycloserine and Pyrimethamine and, equal as the first line anti-TB Ethambutol.

We describe an efficient and convergent synthesis of a series of (1′S,2R,4′S -3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes] displaying potency for the α7 nicotinic acetylcholine receptor (nAChR) and good selectivity vs. the related 5-HT3A receptor.

Importantly, as expected from the FRET melting assay, after 30 min of UV irradiation the caged compound displayed potency comparable to that of the free, active quadruplex ligand.

Indeed, C6 and C7 were effective agonists at this variant and now displayed potency akin to that at the bovine ortholog (Fig. 7 A, B).

As shown in Table 1, these two compounds, compounds 5 and 6, displayed potency in several of our biochemical assays that was similar to the potency of compound 3 (IC50 values within 5 10-fold).

The majority of currently available promiscuous compounds is active in the sub-µM range against two to five targets from the same family and displays potency differences against these targets within one or two orders of magnitude.