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We worked closely with staff at WormBase to develop a graphical display of deletion extents in the genome browser, and to streamline data submission protocols to minimize the time between submission and appearance.
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Furthermore, one sample displayed evidence of deletion of locus CT1291.
Interestingly, most of the cyanophages-encoded D1 proteins display the deletion of the first 58 to 94 amino acids, a region which, in the eukaryotic and cyanobacterial D1 proteins, is extremely rich in oxidative damage prone residues.
The involvement of NHEJ in AZFc deletions can be inferred from the presence of deletion breakpoints displaying the addition of untemplated nucleotides and flanked by non-homologous sequences.
This process resulted in listing for each external stimulus the repertoire of deletion strains that display a growth defect in its presence.
Table 2 displays the number of deletions shared by all pairs of strains.
Interestingly, highly invasive and/or pathogenic strains of serotypes 4b, 1/2a, 1/2b, and 1/2c also displayed a range of deletions here, indicating a certain amount of redundancy of these functions [ 18, 31, 32].
However, the acceptor splice site of downstream intron 8 displays a deletion of G at position +4.
In our subgroup of 7 male patients, 3 (42.8%) displayed a deletion of a common region spanning from Yq11.223 through the centromere to the Yp11.31 band.
These data suggest that only 1p loss rather than 19q loss predict better survival in the subgroup of GBM patients with 1p loss, distinct from OD patients that display co-deletions of 1p and 19q.
Although SIRT1-ΔExon8 dispartialartial deletion of the deacetylase domain, it retains some deacetylation activity (Figure 6).
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