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Although several OTU members display marked selectivity towards certain ubiquitin chain linkages, the majority of DUBs, especially those belonging to the USP group, display no significant intrinsic selectivity towards ubiquitin chain topologies (Rago et al, 2007; Faesen et al, 2011; Ritorto et al, 2014).
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Substitutions on the aromatic ring of the compounds produced compounds that displayed marked selectivity for α4β2 or α4β2α5 nAChRs.
Taken together, the data suggest that compound 1 displays marked selectivity for cancer cells over normal cells.
Allosteric inhibitors of MEK are particularly promising as they exhibit marked selectivity for MEK over other protein kinases.
The sensor exhibits marked selectivity and sensitivity towards Fe3+, with a chelation-induced "off-on" response.
Of note, we observed marked selectivity in P2 preference for falcipains using small peptide substrates.
CGP 20712A and ICI 118551 clearly demonstrated marked selectivity in the rat studies.
Hence, RCC cells display marked HIF- α chain selectivity in target gene responses that likely underlie differences in the role of these molecules in promoting tumour growth.
Besides their similarities, the LTSRs also display marked differences.
The damp display marks Sun Tzu's supposed birthday.
May Wilson displayed marked artistic ability from an early age.
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