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In Drosophila melanogaster, metamorphosis is the period in development when the male and female larval forms, which display little morphological sexual dimorphism, are transformed into the reproductive male and female adult forms, which display large differences between the sexes.
Moreover, automated annotation based on inter-species comparisons has difficulties in identifying species-specific proteins, a problem that is relevant especially to large protein families that display large differences between species.
One possible interpretation of these data that could explain the apparent disparity between two compounds like 49 and 46 is that for compounds such as 49 that display large differences between their Aβ42 IC50 and their Aβ38 EC50 one or more of the shorter peptides (e.g., Aβ37, Aβ34, and/or Aβ33) are actually potentiated at concentrations of SGSMs similar to those required for inhibiting Aβ42.
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In general, while there were significant differences between groups on most variables due to the large sample sizes involved, the groups did not display large differences in demographic characteristics or on their AUDIT-C scores.
Tumors with high COX-2 expression displayed large differences in gene expression compared to normal colon.
The outliers displayed large differences in allele frequencies among major cod populations.
Further, the poverty figures display great differences between regions.
Because ligand potencies and their associated transducer ratios can vary widely, a signaling bias may result in which different ligands produce variable degrees of response in a single pathway or a single ligand displays large differences in efficacy between two independent signaling pathways.
Nevertheless, several microsatellites displayed large frequency differences between the species.
Orlistat exhibited the highest pore water based bioconcentration factors (BCFs) and displayed the largest differences between soil types with BCFs ranging between 30.5 and 115.9.
Ependymin displayed the largest differences between members of the stable hierarchy; thus, the subdominant was 6.5-fold greater than in the subordinate group and 1.6-fold greater than the dominant group.
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