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PS1-KI hippocampal neurons also display increased vulnerability to excitotoxicity as well as deregulation of intracellular Ca2+.
Considering the possible implication of reduced PGC-1α activity in aging, we next sought to investigate whether PGC1α-KO mice display increased vulnerability to the accumulation of human aSyn, a key actor in PD pathology.
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Similarly, HEK293 cells over-expressing Kv2.1 displayed increased vulnerability to oxidant-induced apoptosis, and this was also prevented by CO inhibition of Kv2.1.
Yang, L. et al. Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.
Teenage girls show increased vulnerability to anxiety disorders and depression compared to boys [ 20, 21].
Yet, this IC1270-inducible ISR response seems to act as a double-edged sword within the rice defense network as induced plants displayed an increased vulnerability to the necrotrophic pathogens Rhizoctonia solani and Cochliobolus miyabeanus.
Additionally, neurons from membralin mutant mice display increased basal ER stress and increased vulnerability to ER stress-inducing agents.
Although our parkin-deficient zebrafish did not display obvious morphological alterations, they were characterized by an increased vulnerability to stress-induced cell death.
The result is increased vulnerability to asthma.
Nato ally Turkey will face increased vulnerability to Isis.
The conditions could have increased vulnerability to flu.
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