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Human NKT cells can be subdivided into CD4+ and CD4− subsets, which display functionally distinct cytokine secretion profiles [27], [28], [35].
This may introduce a potential limitation in our study, as bacteria-expressed Cyr61 may not display functionally important glycosylation that may be necessary for activity or take part in the folding of a particular (micro domain of the protein.
TCR and α4β1 outside-in signalling are integrated through the common use of TCR ESC proteins; however, these proteins display functionally distinct roles in these pathways.
It is clear from our results that TCR ESC proteins display functionally distinct roles in TCR and α4β1 outside-in signalling pathways.
This is consistent with the general paucity of classical polymorphic toxin systems in most archaea; though haloarchaea display functionally related PVC-SS delivered toxin systems (See below for further discussion).
Redundancy is observed at multiple levels within biochemical networks – we have already mentioned one example in that mutations within a network modules display functionally equivalent (or at least highly similar) effects.
Similar(54)
The results showed that the diagnostic performance was improved by displaying functionally abstracted information at both levels, and that the usefulness of the abstract information was dependent on the complexity of the diagnosis problems.
In this study we applied the secretome-selective phage display method at a metagenomic scale, in combination with next-generation sequencing, and showed that it efficiently displayed functionally and taxonomically diverse secretome proteins, further focusing sequencing effort onto a subset of biologically relevant sequences from a very complex microbial community.
To this end, it has been demonstrated recently that most, if not all, jawed vertebrate taxa display a functionally similar but specific mucosal immunoglobulin isotype IgA (mammals and birds), IgX (amphibians), or IgT (bony fish) [39].
A threat display is functionally intuitive when performed by toxic or otherwise unprofitable prey, but why predators should refrain from attacking palatable and harmless prey when performing threat displays is still debated (Ruxton et al. 2004; Olofsson et al. 2011).
Therefore, an approach to display multiple functionally active antibody molecules on the surface of pseudotype VLPs that can be easily purified by density-gradient centrifugation may provide a promising alternative to other currently available methods for producing recombinant antibodies.
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