Exact(5)
While pluripotent stem cells can differentiate into all cell types of an organism, MSCs display differentiation restricted to cell types of the connective/myoid tissue such as osteoblasts, adipocytes, chondrocytes and myocytes (Phinney and Prockop, 2007).
Next, we tested whether D-cbl mutant clones display differentiation defects.
Embryos lacking PTBP1 did not display differentiation into the 3 germ layers and cavitation of the epiblast, which are hallmarks of gastrulation.
Fewer studies have examined hMSCs but due to their multipotency and large expansion potential [36] they are appealing for tissue engineering and since they display differentiation sensitivity to substrate stiffness [6], understanding their response to the mechanical properties of biological gels is essential for rational biomaterial design.
By late gastrula stage, the embryos are smaller than controls, and display differentiation and/or patterning defects in all of the major tissue territories: the ectoderm is radialized, the primary mesenchyme cells fail to undergo skeletogenesis, and the gut rudiment is short, disorganized, and typically evaginates as an exogastrula.
Similar(55)
Regions that display differentiation-dependent changes in hypersensitivity were used to predict binding sites for proteins involved in adipogenesis.
The DEM was designed to avoid evoking these concepts, both related to the pattern being displayed: differentiation between trunk and branches, and the metaphor of upward progress.
Cell cycle analyses at day 7 identified a marked G1 cell cycle arrest in those cell lines that displayed differentiation in response to B/M (data not shown).
Mice implanted with HLA-A*0201+ HLA-A*0201+ue displayed differenthymicn of tissueucedisplayedto mature Cdifferentiation that expressed the transgenic SL9 specific TCR whereas mice implanted with HLA-A*0201- thymic tissue initially develofed immatransducedmCD8- and CD4+CD8+ tHSCscytes[30], but no mature CD4-CD8+ cells were observed (Fintoe 3B).
More than 800 protein spots were detected and 100 altered spots displayed differentiation.
These cultures displayed differentiation soon after plating, as shown by almost complete lack of BrdU-positive cells on day in vitro (DIV) 1 3, similar to wild-type cultures (Fig. 7A F).
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