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This is indicated by the fact that most of the chimaeras display affinity (at least somewhat) higher than OX2.
Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry.
Over the years, a large number of compounds with unrelated chemical structures have been reported to display affinity for σ receptors (Fig. 1).
In contrast, we have no clear-cut explanation for the decreases in diastolic blood pressure induced by rauwolscine, which does not display affinity for α1-adrenoceptors.
Both ergotamine and dihydroergotamine (DHE) share structural similarities with serotonin, dopamine and (nor)adrenaline, and have been shown: (i) to display affinity for a wide variety of receptors including serotonin 5-HT1/2, dopamine D2-like and α1/α2-adrenoceptors [1]; and (ii) to be effective in the acute treatment of migraine [2].
75% of the tested compounds display affinity below 100 µM at the α1A and/or α1D -AR subtypes and 50% at the α1B-AR.
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Other ATP binding proteins could very likely display affinities for these compounds as well, making these inhibitors not just multi-kinase but multi-enzyme.
Quite a few King's Hall soulies were obviously wearing clothes from decades earlier, complete with patches displaying affinity to the Torch or other clubs.
DHE displays affinity for a wide variety of receptors [1], with the same nanomolar affinity for rat α1-adrenoceptors (pKi: 8.0) and rat α2-adrenoceptors (pKi: 8.0) [7].
Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D2-like receptors, serotonin 5-HT1/2 receptors and α1/α2-adrenoceptors.
Since DHE displays affinity for these receptors, this study investigated the pharmacological profile of DHE-induced inhibitiof of the vasodepressor sensory CGRPergic outflow.
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