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Overall, 31% (n = 42) of Ppt1- embryos display abnormality at stage 12.
Glioma cells have been reported to display abnormality in one or more genes responsible for regulating cell-cycle progression.
To investigate the molecular components in thermotactic plasticity, we conducted a forward genetic screen and isolated aho-3(nj15) mutants that display abnormality in thermotactic plasticity (Mohri et al. 2005).
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Transgenic mice carrying a mutated human UNC119 transgene develop fundus lesions, display abnormalities in ribbon synapses and abnormal ERG responses, suggesting that retinal degeneration might be caused by defects in trans-synaptic transmission (Kobayashi et al., 2000).
The relevance of this is underscored by clinical findings that IBD patients have an increased risk of thromboembolic complications and display abnormalities in thrombin generation, platelet activation and function [52, 53].
Similarly, psychiatric patients can display abnormalities in the expression of cytokines and neurotrophic factors.
Several genetically-modified animals have been reported to display abnormalities in the body wall region.
Previous studies demonstrated that APP mice display abnormalities in synaptic transmission and long-term potentiation (LTP) [16], [17], [18], [19].
Bipolar disorder patients often display abnormalities in circadian rhythm, and they are sensitive to irregular diurnal rhythms.
If dcr-2 embryos have a decreased tolerance to differences in developmental rates, they will presumably display abnormalities in timing of development at more extreme uniform temperatures.
They do display abnormalities of hair follicle function (26).
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